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\"\"<\/figure>\n\n\n\n

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BMC Public Health\uff08\u539f\u8457\u8ad6\u6587\uff1aCoffee consumption and the risk of chronic liver disease\uff09<\/a><\/p>\n\n\n\n

PubMed\uff08\u30b3\u30fc\u30d2\u30fc\u6442\u53d6\u3068\u6162\u6027\u809d\u75be\u60a3\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u5927\u898f\u6a21\u8abf\u67fb\uff09<\/a><\/p>\n\n\n\n

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\u203b\u51fa\u5178\uff1a<\/p>\n\n\n\n

Cancer Biomark 2016; 16(1): 171-180<\/a><\/p>\n\n\n\n

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\u2461 \u9244\u306e\u5438\u53ce\u6291\u5236\u306b\u3088\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u8efd\u6e1b<\/h3>\n\n\n\n

\u3082\u3046\u4e00\u3064\u3001\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u4f53\u5185\u3078\u306e\u9244\u306e\u5438\u53ce\u6291\u5236\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u98df\u4e8b\u306b\u542b\u307e\u308c\u308b\u9244\u306e\u5438\u53ce\u304c\u4fc3\u9032\u3055\u308c\u3001\u809d\u81d3\u306b\u8caf\u8535\u3055\u308c\u308b\u9244\u304c\u5897\u52a0\u3057\u307e\u3059\u3002\u904e\u5270\u306a\u9244\u306f\u4f53\u5185\u3067\u5f37\u3044\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u751f\u307f\u51fa\u3057\u3001\u809d\u7d30\u80de\u3092\u50b7\u3064\u3051\u308b\u539f\u56e0\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u30b3\u30fc\u30d2\u30fc\u306b\u542b\u307e\u308c\u308b\u6210\u5206\u306f\u3001\u98df\u4e8b\u4e2d\u3084\u98df\u76f4\u5f8c\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u3053\u306e\u9244\u306e\u5438\u53ce\u3092\u963b\u5bb3\u3059\u308b\u50cd\u304d\u304c\u3042\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u304a\u9152\u306b\u3088\u3063\u3066\u5897\u3048\u3059\u304e\u3066\u3057\u307e\u3046\u9244\u306e\u84c4\u7a4d\u3092\u30b3\u30fc\u30d2\u30fc\u304c\u30d6\u30ed\u30c3\u30af\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u809d\u81d3\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u9632\u3044\u3067\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n

\u25a04. \u5fd8\u308c\u3066\u306f\u306a\u3089\u306a\u3044\u6700\u5927\u306e\u8981\u56e0\u3068\u809d\u81d3\u75c5\u5c02\u9580\u533b\u304b\u3089\u306e\u30e1\u30c3\u30bb\u30fc\u30b8<\/strong><\/h2>\n\n\n
\n
\"\"<\/figure>\n<\/div>\n\n\n

\u30b3\u30fc\u30d2\u30fc\u306b\u512a\u308c\u305f\u809d\u4fdd\u8b77\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u306f\u4e8b\u5b9f\u3067\u3059\u304c\u3001\u3060\u304b\u3089\u3068\u3044\u3063\u3066\u300c\u30b3\u30fc\u30d2\u30fc\u3055\u3048\u98f2\u3093\u3067\u3044\u308c\u3070\u809d\u81d3\u75c5\u306b\u306a\u3089\u306a\u3044\u300d\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

\u7279\u306b\u65e5\u672c\u306b\u304a\u3051\u308b\u539f\u767a\u6027\u809d\u304c\u3093\u306e\u7d0480\u30d1\u30fc\u30bb\u30f3\u30c8\u306fC\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u3001\u7d0410\u30d1\u30fc\u30bb\u30f3\u30c8\u306fB\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u304c\u539f\u56e0\u3067\u3059\u3002\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u3066\u3044\u306a\u3044\u4eba\u306e\u5834\u5408\u3001\u30b3\u30fc\u30d2\u30fc\u306b\u3088\u308b\u809d\u304c\u3093\u4e88\u9632\u306e\u30e1\u30ea\u30c3\u30c8\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u809d\u81d3\u3092\u5b88\u308b\u305f\u3081\u306e\u6700\u512a\u5148\u4e8b\u9805\u306f\u3001\u307e\u305a\u3054\u81ea\u8eab\u304c\u809d\u708e\u30a6\u30a4\u30eb\u30b9\u691c\u67fb\u3092\u53d7\u3051\u3001\u611f\u67d3\u306e\u6709\u7121\u3092\u6b63\u3057\u304f\u77e5\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u904e\u98df\u3084\u80a5\u6e80\u306b\u4f34\u3046\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306e\u80cc\u666f\u304b\u3089\u9032\u884c\u3059\u308b\u8102\u80aa\u809d\uff08MASLD\uff1a\u4ee3\u8b1d\u7570\u5e38\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\u3084MASH\uff1a\u4ee3\u8b1d\u7570\u5e38\u95a2\u9023\u8102\u80aa\u809d\u708e\uff09\u306b\u3064\u3044\u3066\u3082\u3001\u98df\u4e8b\u3084\u904b\u52d5\u3068\u3044\u3063\u305f\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u304c\u5927\u524d\u63d0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3010\u809d\u81d3\u75c5\u5c02\u9580\u533b\u306e\u8996\u70b9\uff1a\u4f53\u91cd\u3088\u308a\u3082\u5185\u81d3\u8102\u80aa\u306e\u8cea\u3011<\/strong><\/h3>\n\n\n\n

\u79c1\u306e\u7814\u7a76\u3067\u306f\u3001\u898b\u305f\u76ee\u306f\u75e9\u305b\u3066\u3044\u3066\u3082\u5185\u81d3\u8102\u80aa\u304c\u84c4\u7a4d\u3057\u3066\u3044\u308b\u300c\u96a0\u308c\u80a5\u6e80\u300d\u306e\u65b9\u306f\u3001\u809d\u304c\u3093\u6cbb\u7642\u5f8c\u306e\u4e88\u5f8c\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u203b\u51fa\u5178\uff1a<\/p>\n\n\n\n

J Cancer Ther 2015; 6: 1124-1136<\/a><\/p>\n\n\n\n

\u809d\u81d3\u3092\u5b88\u308b\u305f\u3081\u306b\u306f\u3001\u307e\u305a\u3053\u3046\u3057\u305f\u5185\u81d3\u8102\u80aa\u3092\u6e1b\u3089\u3059\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u304c\u5927\u524d\u63d0\u3067\u3059\u3002\u305d\u306e\u4e0a\u3067\u3001\u4eca\u56de\u3054\u7d39\u4ecb\u3057\u305f\u30b3\u30fc\u30d2\u30fc\u304c\u6301\u3064\u6297\u9178\u5316\u4f5c\u7528\u306a\u3069\u3092\u3001\u65e5\u3005\u306e\u52aa\u529b\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u4e00\u3064\u306e\u300c\u55dc\u597d\u54c1\u300d\u3068\u3057\u3066\u4e0a\u624b\u306b\u53d6\u308a\u5165\u308c\u3066\u3044\u304f\u306e\u304c\u6700\u3082\u5065\u5eb7\u7684\u3068\u8a00\u3048\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n

\u25a0\u3088\u304f\u3042\u308b\u3054\u8cea\u554f\uff08Q\uff06A\uff09<\/strong><\/h2>\n\n\n
\n
\"\"<\/figure>\n<\/div>\n\n\n

Q1. <\/strong>\u30b3\u30fc\u30d2\u30fc\u306f\u30a4\u30f3\u30b9\u30bf\u30f3\u30c8\u3084\u7f36\u30b3\u30fc\u30d2\u30fc\u3067\u3082\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><\/p>\n\n\n\n

A1. \u306f\u3044\u3001\u30a4\u30f3\u30b9\u30bf\u30f3\u30c8\u30b3\u30fc\u30d2\u30fc\u3067\u3082\u540c\u69d8\u306e\u6297\u9178\u5316\u6210\u5206\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u305f\u3081\u52b9\u679c\u306f\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u7f36\u30b3\u30fc\u30d2\u30fc\u306e\u5834\u5408\u306f\u300c\u5fae\u7cd6\u300d\u3067\u3042\u3063\u3066\u3082\u7cd6\u8cea\u304c\u591a\u304f\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308b\u305f\u3081\u3001\u5fc5\u305a\u300c\u7121\u7cd6\uff08\u30d6\u30e9\u30c3\u30af\uff09\u300d\u3092\u9078\u3076\u3088\u3046\u306b\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n

Q2. <\/strong>\u82e6\u3044\u306e\u304c\u82e6\u624b\u306a\u306e\u3067\u3059\u304c\u3001\u7802\u7cd6\u3084\u30df\u30eb\u30af\u306f\u5165\u308c\u3066\u3082\u3044\u3044\u3067\u3059\u304b\uff1f<\/strong><\/p>\n\n\n\n

A2. \u809d\u81d3\u3092\u5b88\u308b\u76ee\u7684\u3067\u3042\u308c\u3070\u3001\u30d6\u30e9\u30c3\u30af\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002\u7802\u7cd6\u3084\u7518\u3044\u30b7\u30ed\u30c3\u30d7\u306b\u542b\u307e\u308c\u308b\u7cd6\u8cea\uff08\u7279\u306b\u679c\u7cd6\uff09\u306f\u809d\u81d3\u3067\u4e2d\u6027\u8102\u80aa\u306b\u5909\u308f\u308a\u3084\u3059\u304f\u3001\u304b\u3048\u3063\u3066\u8102\u80aa\u809d\uff08MASLD\uff09\u3092\u60aa\u5316\u3055\u305b\u308b\u539f\u56e0\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

Q3. 1<\/strong>\u65e5\u306b\u4f55\u676f\u304f\u3089\u3044\u98f2\u3081\u3070\u3044\u3044\u3067\u3059\u304b\uff1f<\/strong><\/p>\n\n\n\n

A3. 1\u65e52\u301c3\u676f\u7a0b\u5ea6\u304c\u3072\u3068\u3064\u306e\u76ee\u5b89\u3068\u306a\u308a\u307e\u3059\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u4e0a\u306f\u98f2\u3080\u307b\u3069\u30ea\u30b9\u30af\u304c\u4e0b\u304c\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u98f2\u307f\u3059\u304e\u308b\u3068\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u904e\u5270\u6442\u53d6\u306b\u3088\u308a\u80c3\u8178\u3078\u306e\u8ca0\u62c5\u3084\u7761\u7720\u306e\u8cea\u306e\u4f4e\u4e0b\u3092\u62db\u304f\u6050\u308c\u304c\u3042\u308b\u305f\u3081\u3001\u3054\u81ea\u8eab\u306e\u4f53\u8abf\u306b\u5408\u308f\u305b\u3066\u9069\u91cf\u3092\u304a\u697d\u3057\u307f\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n

Q4. <\/strong>\u30ab\u30d5\u30a7\u30a4\u30f3\u30ec\u30b9\uff08\u30c7\u30ab\u30d5\u30a7\uff09\u3067\u3082\u52b9\u679c\u306f\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><\/p>\n\n\n\n

A4. \u306f\u3044\u3001\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u7814\u7a76\u3067\u306f\u30ab\u30d5\u30a7\u30a4\u30f3\u4ee5\u5916\u306e\u300c\u30af\u30ed\u30ed\u30b2\u30f3\u9178\u300d\u306a\u3069\u306e\u6297\u9178\u5316\u7269\u8cea\u304c\u809d\u81d3\u3092\u4fdd\u8b77\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306b\u654f\u611f\u306a\u65b9\u3084\u591c\u306b\u98f2\u307f\u305f\u3044\u65b9\u306f\u30c7\u30ab\u30d5\u30a7\u3092\u9078\u3093\u3067\u3044\u305f\u3060\u3044\u3066\u5168\u304f\u554f\u984c\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

\u25a0\u307e\u3068\u3081\u2014\u2014\u8ae6\u3081\u306a\u3044\u809d\u81d3\u518d\u751f\u533b\u7642\u3068\u3044\u3046\u9078\u629e\u80a2<\/strong><\/h2>\n\n\n
\n
\"\"<\/figure>\n<\/div>\n\n\n

\u795e\u6238\u5e02\u897f\u533a\u306e\u3055\u3044\u3068\u3046\u5185\u79d1\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u809d\u81d3\u75c5\u5c02\u9580\u533b\u306e\u8996\u70b9\u304b\u3089\u3001\u65e5\u5e38\u7684\u306a\u691c\u67fb\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u30a2\u30c9\u30d0\u30a4\u30b9\u306f\u3082\u3061\u308d\u3093\u3001\u6a19\u6e96\u6cbb\u7642\u3060\u3051\u3067\u306f\u6539\u5584\u304c\u96e3\u3057\u3044\u9032\u884c\u3057\u305f\u809d\u786c\u5909\u306a\u3069\u306b\u5bfe\u3057\u3066\u3001\u60a3\u8005\u69d8\u3054\u81ea\u8eab\u306e\u7d30\u80de\u3092\u7528\u3044\u305f\u300c\u809d\u81d3\u518d\u751f\u533b\u7642\uff08\u81ea\u5df1\u8102\u80aa\u7531\u6765\u5e79\u7d30\u80de\u7642\u6cd5\uff09\u300d\u3068\u3044\u3046\u9078\u629e\u80a2\u3082\u3054\u63d0\u6848\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u9060\u65b9\u306b\u304a\u4f4f\u307e\u3044\u3067\u901a\u9662\u304c\u96e3\u3057\u3044\u65b9\u306e\u305f\u3081\u306b\u3001\u30b9\u30de\u30fc\u30c8\u30d5\u30a9\u30f3\u304b\u3089\u6c17\u8efd\u306b\u76f8\u8ac7\u3067\u304d\u308b\u30aa\u30f3\u30e9\u30a4\u30f3\u4e8b\u524d\u76f8\u8ac7\uff08Curon\uff09\u3082\u3054\u7528\u610f\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u30a4\u30f3\u30bf\u30fc\u30cd\u30c3\u30c8\u306e\u64cd\u4f5c\u304c\u82e6\u624b\u306a\u65b9\u306f\u3001\u8a3a\u7642\u6642\u9593\u5185\u306b\u304a\u96fb\u8a71\u3092\u3044\u305f\u3060\u3044\u3066\u3082\u69cb\u3044\u307e\u305b\u3093\u3002\u9662\u9577\u306e\u5916\u6765\u8a3a\u7642\u304c\u843d\u3061\u7740\u304d\u307e\u3057\u305f\u3089\u3001\u3053\u3061\u3089\u304b\u3089\u304a\u96fb\u8a71\u3092\u304b\u3051\u76f4\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

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